Endocrine Abstracts

Background: Nonclassic congenital adrenal hyperplasia (NCAH) is a condition associated with adrenal masses and suggested by current European guidelines to be considered in case of bilateral adrenal lesions. NCAH is caused by different mutations in the CYP21A2 gene coding for the 21-hydoxylase enzyme in the glucocorticoid synthesis leading to mild cortisol deficiency and elevated androgen and steroid precursor levels. 17-hydroxyprogesterone (17OHP) is the most importan...

Background: Resource-saving and medically safe investigations of adrenal incidentaloma (AI) is one of the challenges in modern endocrinology. The absolutely majority of AIs are benign and hormonally inactive. Mild hypercortisolemia is the most common finding in hormonally active AI and is often referred to as subclinical Cushing syndrome (SCS). SCS is associated with increased risk of type 2 diabetes, poorly regulated hypertension, osteoporosis and cardiovascular disease. Ther...

Background: Adrenal incidentalomas (AI) are common and reported at frequencies of 2-10% at CT-scans of the abdomen. It is established that the number of diagnosed and investigated cases of AI have increased over the last decades. This increase is closely related to the development of modern radiology. General access of CT scanners with higher performance have led to an improved capacity and consequently more performed investigations. Other contributing factors are improved ima...